Pep Guardiola suggested Manchester City would be reluctant to switch the October meeting with Tottenham to a home fixture as their Premier League counterparts face potential stadium limbo.
City are due travel to face Spurs on October 28 – a game that was initially scheduled to take place at the north London club's new stadium.
But delays in completing the facility on the site of White Hart Lane have led to Tottenham extending their arrangement with Wembley to stage matches versus Liverpool and Cardiff City, along with Saturday's meeting against Fulham.
Spurs' derby against Chelsea on November 24 is listed on their official website as a game that will take place at their new home, although City's visit is slated as "TBC".
The situation is further complicated by the fact Philadelphia Eagles are due to play Jacksonville Jaguars in the NFL on the same day as the City clash at England's national stadium.
Mauricio Pochettino stated on Thursday he would be rather play City the following day on a potentially compromised playing surface than seek another stand-in home ground.
Switching home and away fixtures would leave City travelling to north London on the weekend of April 20 and mean four of their final five Premier League games this season are away from home – a scenario that understandably left Guardiola cold.
"We want to help the Premier League. The club [City] didn't release any statement about that. We don't know absolutely anything," he told a news conference.
You know it, boss! pic.twitter.com/huDVMl3Z35— Manchester City (@ManCity) 16 December 2017
"It can happen because if you build an amazing stadium, sometimes there are delays. We can adapt, we have to think of ourselves as well and, of course, the Premier League.
"All I can say is that if that happens [switching the games] the last five games in the Premier League, four are away. So... I think that's a problem, yeah.
"When you maybe are playing for the Premier League, four games away is a little bit different.
"But I am a manager for what happens for on the pitch and it's enough. In the end, if Tottenham want to suggest something and speak to our CEO and our people, we are going to decide the best for the Premier League.
"At the end, if Tottenham want to suggest something they can speak to our CEO and the best for them and the Premier League we can decide."
There are no such complications surrounding Huddersfield Town being the first visitors to the Etihad Stadium this season, only those on the pitch Guardiola recognises as his jurisdiction.
The champions began their Premier League defence with a 2-0 win over Arsenal last weekend but have been hit by the news a lateral knee ligament injury will deprive them of Kevin De Bruyne for three months.
"Last season was tough, both games," he said, reflecting on a late 2-1 win over David Wagner's Huddersfield, who manged to hold City to a 0-0 draw on home turf.
COME ON!! pic.twitter.com/FtMlrFVUvt— Manchester City (@ManCity) 26 November 2017
"They are tough physically, defensively strong, good set pieces and good counter-attack. They make good high-pressing, they defend deep so well. It was complicated last season and I imagine quite a similar game this time.
"After a tournament like the World Cup, you need a month or a month-and-a-half. In that period these kind of games are so dangerous.
"The players are maybe more focused when you play against Arsenal – a big stage, a big game. When you come with games like Wolves, Cardiff, Fulham – I prefer to take these teams in October or November.
"In this period, the history says the contenders always drop points. They are complicated games."
|Monchi rules out Spain return amid Barcelona rumours|
|Durham skittled for 61 and 66 on the same day|
|Kane isn´t a machine – Lamela defends misfiring Spurs star|
|Hazard left out of Chelsea squad for PAOK trip|
|Tiger feels close to ending drought after achieving Tour Championship goal|
|Leno in line for Arsenal chance in Europa League|
|Gazidis leaves Arsenal in good shape, insists Emery|
|Eagles bring back WR Matthews, place Wallace on IR|
|England include Stokes, Hales and uncapped seamer Stone in ODI squad|
|Suwon Bluewings 0 Jeonbuk Motors 3 (aet, 4-2 on penalties): Quarter-final comeback ends in spot-kick|
|Australia captain Paine ready to slog it out with Pakistan|
|Nadal pulls out of China Open & Shanghai Masters with knee injury|
|Ostapenko begins Korea Open defence with victory|
|Joshua v Povetkin: How Olympic super heavyweight champions have fared|
|Liverpool ´made a point´ with PSG victory - Gomez|
|Osaka wows Tokyo crowd on WTA return|
|Excited Povetkin arrives in England for Joshua showdown|
|Kovac patience with Sanches set to reap rewards|
|Kovac: Madrid strong without Ronaldo, Messi is the best|
|ATP suspends umpire Lahyani over Kyrgios ´pep talk´ at US Open|
|North and South Korea seek to co-host 2032 Olympics|
|Ampadu signs long-term Chelsea contract|
|Don´t blame Neymar, PSG players all guilty - Thiago Silva|
|Real Madrid seek to plug Ronaldo scoring gap – Champions League in Opta numbers|
|Brewers allow Cardinals to inch closer with loss to Reds|
|Manchester is still red – Depay ahead of Lyon´s clash with City|
|Orioles become first pro team to wear braille jerseys|
|Klopp hails ´brilliant´ Henderson|
|PSG attack lacked aggression, says Tuchel|
|Atletico Tucuman 0 Gremio 2: Libertadores holders draw first blood in QFs|
|Thomas plays down wrist worry|
|Rakitic wants more from Barcelona hat-trick hero Messi|
|My players aren´t s*** – Pochettino defends Spurs squad|
|Cubs reliever Morrow won´t return this season|
|Tebow expected to be back in Mets organisation next season|
|Inter can compete against anyone – Icardi revels in Champions League victory|
|Tuchel: PSG loss to Liverpool not logical or correct|
|Sturridge in best shape I´ve seen – Klopp|
|Milojevic celebrates ´fantastic´ occasion after Red Star´s 26-year wait|
|Rodrigo and Simeone salute Griezmann display|
|Seahawks DE Clark on Bears QB Trubisky: He´s nothing special|
|Carroll says Wilson has been ´over-trying a little bit´|
|Judge returns to Yankees´ starting lineup|
|Napoli boss Ancelotti takes aim at Red Star time wasting|
|Favre admits young Dortmund stars struggled in Bruges|
|Otavio would trade goal for Porto victory as he bemoans Schalke draw|
|Championship Review: Pacesetters Leeds crush Preston, Villa end five-game winless run|
|Neymar world-class but not a defender - Klopp says Liverpool targeted PSG star|
|Waiters injury update: Heat guard unlikely to be ready for start of season|
|Gojowczyk eliminates returning Tsonga in Metz|
|Liverpool enjoying best start in 57 years after PSG win|
|Galatasaray 3 Lokomotiv Moscow 0: Terim´s side make light work of Russians|
|Club Brugge 0 Borussia Dortmund 1: Super sub Pulisic scores late winner|
|Schalke 1 Porto 1: Fahrmann saves one penalty, but Otavio scores another|
|Red Star Belgrade 0 Napoli 0: Points shared as Italians fail to make possession pay|
|Liverpool 3 Paris Saint-Germain 2: Firmino strikes late as Reds edge five-goal thriller|
|Monaco 1 Atletico Madrid 2: Costa and Gimenez seal comfortable win|
|Chaos reigns in Serie B as league denies suspension claim|
|India secure Asia Cup victory despite valiant Hong Kong effort|
|Messi makes "extraordinary routine", says Valverde after Barca star surpasses Ronaldo|
|Spalletti´s Inter to take heart from Tottenham turnaround|
|Casillas features in landmark 20th Champions League campaign|
|Spurs deserved more from best performance of the season - Pochettino|
|Brown absent from Steelers facility on Monday due to ´personal matter´|
|Toronto´s Bussey given eight-match biting ban|
|Barcelona 4 PSV 0: Marvellous Messi lights up Camp Nou|
|Inter 2 Tottenham 1: Icardi, Vecino complete dramatic late turnaround|
|Allegri, Chiellini defend Costa over spitting ban|
|Firmino only fit enough for bench duty|
|Kovac applauds Sanches ahead of Benfica homecoming|