Australia head to Twickenham with a spring in their step and eyeing revenge when they face England, while New Zealand take on Scotland and France host South Africa in another mouthwatering Saturday of international rugby.
England retained the Cook Cup by beating the Wallabies last year, but Michael Cheika's men are in fine form 12 months on and Eddie Jones' side must raise their game after a disjoined display in the win over Argentina.
World champions New Zealand head to Murrayfield on the back of being outplayed by France in the second half at Stade de France last weekend, having been outstanding in the opening 40 minutes to set up a victory in Paris.
Les Bleus will fancy their chances of seeing off a Springboks side that was hammered by Ireland, who should see off Fiji at the Aviva Stadium. Wales will aim to take the frustration of their latest loss to Australia out on Georgia.
With the help of Opta, we take a statistical look at the five Tests.
England v Australia
The Six Nations champions have won their last four matches against Jones' country of birth, including a 3-0 whitewash in Australia last year.
Australia have scored 55 tries in 2017, only twice have they scored more in a calendar year (64 in 2003, 56 in 1998).
England, who welcome Owen Farrell back into the side with Maro Itoje on the bench, are unbeaten in 12 games at Twickenham, their second-best sequence of victories at home. They won 22 in a row from October 1999 to September 2003.
France v South Africa
The Springboks whitewashed France 3-0 on home soil in June, all three victories by a margin of at least 22 points.
However, Les Bleus have come out on top in four of their last five home Tests against South Africa.
Antoine Dupont made four clean breaks, beat seven defenders and made 91 metres against New Zealand last Saturday. Since the 2015 Rugby World Cup, no tier one scrum-half has matched any of those statistics.
Ireland v Fiji
Joe Schmidt's side may not have expected to beat South Africa so emphatically, but they will be expected to rack up the points this weekend.
Ireland, who have handed a debut to centre Chris Farrell, have played only three Tests against Fiji, winning all three by 35 points or more.
Fiji wing Josua Tuisova has won 12 turnovers for Toulon in the TOP 14 this season, more than any other player in the competition this season, he's also crossed for five tries in his seven appearances.
Scotland v New Zealand
The All Blacks have never been beaten by Scotland in 30 Tests, only twice being held to a draw.
None of the current Scotland squad were born the last time they avoided defeat against the All Blacks – a 25-25 draw in 1983 – while Wyatt Crockett and Jerome Kaino are the only players in the world champions' touring squad to be born before that clash.
Scotland have won their last five matches at Murrayfield, their best winning sequence at the famous venue since a 13-game run from 1989 to 1991.
Wales v Georgia
This will be the first Test meeting between the two nations and Georgia will be looking for a first win against tier one opposition.
Wales missed just three of 153 attempted tackles [98 per cent success rate] against the Wallabies, the last time they missed fewer was in 2013 against Scotland. However, the 20 turnovers conceded was their highest figure in 15 matches.
Georgia full-back Soso Matiashvili scored 34 points against Canada last weekend, the most ever by a Lelos player in a Test match.
|Messi to miss Argentina´s upcoming friendlies|
|Dolphins say Hayes tore ACL attempting to avoid roughing-the-passer penalty|
|Modric deserved FIFA Best award – Ramos|
|Thibodeau open to potential Butler trade|
|Modric wanted Ronaldo, Messi at awards ceremony|
|Brewers´ Yelich active after elbow hit|
|Anthony on coming off Rockets´ bench: Whatever I have to do to help this team win|
|Raiders coach Gruden says Mack trade was hard on players|
|Bale lauds ´unbelievable´ Modric after FIFA Best triumph|
|Ronaldo, Messi lacked respect with FIFA Best awards snub - Capello|
|New Zealand the benchmark but England can win World Cup - Mitchell|
|FIFA Best Award a dream come true for Modric|
|Lakers a long way from Warriors, warns LeBron|
|Milner pokes fun at Salah´s Puskas Award win|
|Josh Rosen to replace Sam Bradford as Cardinals starting quarterback|
|Kaymer: Home-course advantage crucial to Europe hopes|
|Marta and Pedros win FIFA Best awards|
|I want to be in Toronto - Kawhi Leonard focused on Raptors, not future|
|Messi and Ronaldo lead FIFPro World XI as Salah and Neymar miss out|
|Knicks´ Kristaps Porzingis ´itchy´ to return but won´t commit to 2018-19 season|
|Modric beats Ronaldo and Salah to FIFA Best prize|
|49ers confirm ACL tear for QB Garoppolo|
|Salah beats Bale and Ronaldo to Puskas Award|
|Deschamps wins FIFA Best Men´s Coach award|
|Law to leave Windies for Middlesex role|
|Sunderland terminate Ndong´s contract|
|Spalletti warns rejuvenated Inter against complacency|
|Ryder Cup 2018: Figo in town as USA arrive in style|
|Browns name Baker Mayfield starting QB|
|Chelsea need to be more versatile, warns Giroud|
|Paris Saint-Germain FFP case referred by UEFA back to CFCB Investigatory Chamber|
|Busy Bertens ready for bed, Muguruza gains Wimbledon revenge|
|Hart ready if England come calling - Dyche|
|Ryder Cup 2018: An honour and a burden - the unique challenge of captaincy|
|Hibino beats Bouchard again at the Tashkent Open|
|Falcons lose Ricardo Allen for season|
|Mbappe three-match ban stands following appeal|
|Tomic wins first Tour-level match since Wimbledon in Chengdu|
|Ryder Cup diary: Scoreboard shocker, captains tight-lipped|
|Mourinho will spawn lots of managers - Lampard|
|Furyk outlines Woods´ Ryder Cup motivation|
|Tiger doesn´t scare Team Europe - Bjorn|
|Ryder Cup 2018: Team USA profile|
|Woods winning ´incredibly special for golf´, says Poulter|
|Grealish commits to Aston Villa with five-year deal|
|Ryder Cup 2018: Four reasons why Team USA will win|
|Herrera ready for return - Mourinho|
|Bellew determined to prove doubters wrong against Usyk|
|Lewandowski and Boateng´s professionalism impresses Kovac|
|WATCH: Sheepish Murray comically drops commemorative plate in China|
|Cech: Arsenal have forgotten how to win Premier League titles|
|Lemar must adapt to Atleti style, says Simeone|
|Toulon to appeal suspended points penalty|
|AFE rejects Miami plan for Girona-Barca|
|Messi and Ronaldo to decide world´s best young player|
|Ryder Cup 2018: Talisman Poulter key to European hopes|
|Pogba hits out at critics who ´create drama´|
|Barcelona to appeal Lenglet red card|
|Ryder Cup 2018: Team Europe profile|
|Patriots´ Gronkowski threatened to retire if traded to Lions|
|Ryder Cup 2018: Four reasons why Europe will win|
|Tigres and Monterrey condemn violence that leaves fan in intensive care|
|Williams baffled by coach´s claim he sent her US Open final signals|
|Ryder Cup 2018: A sporting spectacular you cannot afford to miss|
|Cricket Australia closes investigation into Moeen claim|
|Zlatan impressed by ´MVP´ singer|
|Modric hoping to complete FIFA and UEFA double at Best Awards|
|Mickelson never doubted Woods would win again|
|Woods looked like Tiger of old in 80th PGA Tour win|
|Chelsea were too slow against West Ham - David Luiz|