Australia head to Twickenham with a spring in their step and eyeing revenge when they face England, while New Zealand take on Scotland and France host South Africa in another mouthwatering Saturday of international rugby.
England retained the Cook Cup by beating the Wallabies last year, but Michael Cheika's men are in fine form 12 months on and Eddie Jones' side must raise their game after a disjoined display in the win over Argentina.
World champions New Zealand head to Murrayfield on the back of being outplayed by France in the second half at Stade de France last weekend, having been outstanding in the opening 40 minutes to set up a victory in Paris.
Les Bleus will fancy their chances of seeing off a Springboks side that was hammered by Ireland, who should see off Fiji at the Aviva Stadium. Wales will aim to take the frustration of their latest loss to Australia out on Georgia.
With the help of Opta, we take a statistical look at the five Tests.
England v Australia
The Six Nations champions have won their last four matches against Jones' country of birth, including a 3-0 whitewash in Australia last year.
Australia have scored 55 tries in 2017, only twice have they scored more in a calendar year (64 in 2003, 56 in 1998).
England, who welcome Owen Farrell back into the side with Maro Itoje on the bench, are unbeaten in 12 games at Twickenham, their second-best sequence of victories at home. They won 22 in a row from October 1999 to September 2003.
France v South Africa
The Springboks whitewashed France 3-0 on home soil in June, all three victories by a margin of at least 22 points.
However, Les Bleus have come out on top in four of their last five home Tests against South Africa.
Antoine Dupont made four clean breaks, beat seven defenders and made 91 metres against New Zealand last Saturday. Since the 2015 Rugby World Cup, no tier one scrum-half has matched any of those statistics.
Ireland v Fiji
Joe Schmidt's side may not have expected to beat South Africa so emphatically, but they will be expected to rack up the points this weekend.
Ireland, who have handed a debut to centre Chris Farrell, have played only three Tests against Fiji, winning all three by 35 points or more.
Fiji wing Josua Tuisova has won 12 turnovers for Toulon in the TOP 14 this season, more than any other player in the competition this season, he's also crossed for five tries in his seven appearances.
Scotland v New Zealand
The All Blacks have never been beaten by Scotland in 30 Tests, only twice being held to a draw.
None of the current Scotland squad were born the last time they avoided defeat against the All Blacks – a 25-25 draw in 1983 – while Wyatt Crockett and Jerome Kaino are the only players in the world champions' touring squad to be born before that clash.
Scotland have won their last five matches at Murrayfield, their best winning sequence at the famous venue since a 13-game run from 1989 to 1991.
Wales v Georgia
This will be the first Test meeting between the two nations and Georgia will be looking for a first win against tier one opposition.
Wales missed just three of 153 attempted tackles [98 per cent success rate] against the Wallabies, the last time they missed fewer was in 2013 against Scotland. However, the 20 turnovers conceded was their highest figure in 15 matches.
Georgia full-back Soso Matiashvili scored 34 points against Canada last weekend, the most ever by a Lelos player in a Test match.
|Hummels to miss Germany-Sweden, confirms Low|
|Murray accepts Eastbourne wildcard|
|St Petersburg madness lines up Neymar and Brazil with heroes of the past|
|Martinez happy to be ´boring Belgium´|
|Japan v Senegal: Squeaky clean Group H rivals eyeing huge step towards last 16|
|Argentina team the worst in history - Ardiles|
|Ravanelli upsets wife by taking Arsenal job...in Kiev|
|Federer moves a step closer to 10th title in Halle|
|Brazil 2 Costa Rica 0: Coutinho and Neymar score in stoppage time to snatch win|
|Andersson: Sweden embracing big occasion as bug sweeps through team|
|LeBron in ´good dialogue´ with Cavaliers|
|Ronaldo will always be the best, Fonte claims|
|Southgate criticises press for England team leak|
|O´Mahony: Series win in Australia would be up there with Grand Slam|
|Khedira thrilled with Can capture, staying with Juventus|
|Samuel open to Higuain-Icardi swap deal|
|It´s just a game - Milligan disappointed by Kruse criticism|
|From drug-testing lab to gastro pub: Sochi happy not to forget dark past|
|Ronaldo will do what is best for him, says Carvajal|
|Kohli: India will feel at home in England|
|Barca target Lenglet yet to decide future|
|Germany perform best under pressure, Klose claims|
|Juanfran signs one-year Atletico Madrid extension|
|Julian Nagelsmann: The remarkable rise of RB Leipzig|
|Sterling: my daughter is Liverpool through and through!|
|Van Bommel to take charge of PSV|
|Hansen urges France not to ´squeal´ over decisions|
|Intelligent Jones will turn England´s fortunes around - Moody|
|Nainggolan confirms imminent Inter transfer|
|U.S. Open missed cut may be blessing in disguise - McIlroy|
|Schmidt in no rush to decide on his future|
|Wallabies treating decider as grand final - Hooper|
|Salah won´t leave World Cup, Egypt FA boss claims|
|Chandimal, Hathurusinghe and Gurusinha admit ´serious´ conduct breach|
|Mikal Bridges´ 76ers dreams dashed in dramatic draft twist|
|They want to pull you down - Sterling hits out at tabloid press|
|Lazaridis wants West Ham to stick with Mexico star Hernandez|
|Get behind Sterling, urges Henderson|
|Sampaoli begs for Argentina´s forgiveness|
|The 2018 NBA Draft first round in full|
|Everything still to play for against ´very strong´ France, says Eriksen|
|Cubs bested by Harvey, Yankees sweep Mariners|
|Spurs GM: We´ll do what we can to keep Leonard|
|Lovren: This Croatia team are better than 1998 heroes|
|Internationals Musa, Okobo selected in NBA Draft|
|Modric is the world´s best number 10 – Arbeloa|
|Kurz stay crucial to Jakobsen´s Adelaide move|
|Nuggets end Porter´s slide at number 14|
|Argentina were crying like girls – Vrsaljko|
|Cavaliers select Sexton with number eight overall pick|
|Argentina must ´pray´ results go their way, says Mascherano|
|Grizzlies select Jackson with number four pick|
|Hawks select Doncic with third pick, trade him to Mavericks|
|Kings take Bagley with number two pick|
|Suns select Ayton number one overall in NBA Draft|
|Argentina concerns grow as Dalic vows to rest players against Iceland|
|Messi could retire after World Cup, says Zabaleta|
|Spieth, McIlroy off to hot starts at Travelers Championship|
|Let Sampaoli say what he wants - Aguero angry at Argentina loss|
|Perisic: Messi is the best, but Argentina do not play as a team|
|Dominant England are ´spoiled´ by options, says Morgan|
|Argentina squad ´clouds´ Messi´s brilliance, claims Sampaoli|
|Fagner to start for Brazil due to Danilo injury|
|Arzani lauds leader Jedinak and remains confident on last-16 chances|
|Croatia cut Messi off in Argentina thrashing - Modric|
|Pogba: Kante, Matuidi have 15 lungs|
|Julian Nagelsmann: the Bundesliga prodigy swapping Hoffenheim for RB Leipzig|
|England dominate in Durham to close in on series whitewash|
|´Fortunate´ Federer closes in on Halle title|
|Calamity Caballero and Sampaoli tinkerings leave Argentina a broken mess|