Rigoberto Uran has withdrawn from the Tour de France due to injuries suffered on stage nine.
The EF Education First - Drapac rider crashed on the cobbled 156.5 kilometre ride from Arras to Roubaix on Sunday.
Uran, the runner-up in last year's Tour, had the benefit of a rest day on Monday and has since braved two mountain stages, but finished 26 minutes behind Geraint Thomas on stage 11 on Wednesday.
The Colombian is now 31 minutes off the pace and, with his hopes of contending in the general classification gone, Uran has decided to focus on his recuperation.
"I didn't recover after the crash. Yesterday in the first real climb, all day, there was pain in my body," Uran said.
"It's difficult for me and also for my team. We prepared for this Tour, all season we were focused on the Tour.
“Today I have to share some bad news. I didn’t recover after the crash. Yesterday in the first real climb, all day, there was pain in my body.” - @UranRigoberto #PinkArgyle #TDF2018 leader Rigoberto Uran withdraws due to injuries: https://t.co/gvmAB4H6O7 pic.twitter.com/gDO7cuu5Rf— EF Education First - Drapac p/b Cannondale (@Ride_Argyle) July 19, 2018
"Sometimes this happens, and this time, I think it's the best decision for me to recover and to recover well."
With their team leader out, EF Education First - Drapac will focus on simply winning stages for the remainder of the Tour.
"We'll miss Rigo of course – he's a great leader and a wonderful presence to have on the bus and with the staff," said team CEO Jonathan Vaughters. "We look forward to getting him back healthy for the rest of the season.
"The guys that remain are fighters, and we have some chances coming up in the mountains. For us, another Tour begins."
|WATCH: Djokovic wins match, loses car|
|Bolt arrives in Sydney for A-League trial|
|Red-hot Bertens beats Svitolina, Halep marches on|
|Snedeker preserves Wyndham lead|
|Halep hits back to torment Tsurenko|
|Raonic fails to break Djokovic stranglehold|
|Emery seeks more ´demanding´ Ozil|
|CAF Champions League Review: Wydad, Al Ahly & TP Mazembe qualify|
|Stephen Curry wants to finish his career with Warriors|
|Hazard among Europe´s best but can improve, says Sarri|
|Tigers boost top-two hopes, Giants close in on fourth|
|Birmingham City 0 Swansea City 0: Monk´s men held despite dominance|
|Inter taking legal action against Tebas over Modric transfer comments|
|Serie A transfer round-up: Zaza joins Torino, Parma sign Gervinho|
|Roma chief Pallotta makes light of De Laurentiis claim|
|Federer starts double-header by seeing off resilient Mayer|
|Ospina joins Napoli on loan from Arsenal|
|Klavan completes Cagliari switch|
|Djokovic holds out against Dimitrov as Raonic awaits|
|New dates confirmed for postponed Serie A fixtures|
|Halep breezes past Barty to set up Tsurenko clash on same day|
|Olesen unable to capitalise on strong start as Jamieson, Waring go clear|
|Hoffenheim tie Kramaric to four-year deal|
|Mina to miss Southampton clash while Gomes is ´weeks´ away|
|Barcelona coach Valverde dismisses Pogba speculation|
|Valverde not prioritising Champions League over defending Barcelona´s LaLiga title|
|Allegri thanks outgoing Juventus icon Marchisio|
|Pants display from Beef? Johnston forced into change of trousers in Sweden|
|Tour champion Thomas has Welsh velodrome named in his honour|
|Gloucester surprised and disappointed by RFU´s swift Cipriani charge|
|Storm skipper Smith´s back injury not ´too serious´|
|Spurs fixture switch doesn´t appeal to Guardiola|
|Brazil call up Andreas Pereira & Arthur but omit Man City stars|
|Mbappe returns to PSG squad, Kehrer set for debut|
|No Messi in Argentina squad as Simeone wins first call-up|
|England man Roy embarrassed by self-inflicted facial injury|
|Atletico Madrid fined for breaching third-party regulations|
|Cipriani charged by RFU after common assault conviction|
|No contact, no negotiation - Leonardo denies AC Milan deal for Milinkovic-Savic|
|Kovacic set for Chelsea debut against Arsenal|
|Fury´s father restrained as Wilder crashes Pianeta weigh-in|
|Kohli and Bumrah fit for win-or-bust Test|
|Stokes ready and desperate to help England, says Root|
|Salah, Mane and Firmino not in competition says Klopp|
|Darmian staying at Manchester United, says Mourinho|
|Guardiola cites fatigue as factor for stricken De Bruyne|
|Kovac approves Rudy departure from bloated Bayern midfield|
|Klopp insists no player leaves without his approval amid Klavan rumours|
|Real Madrid complain to FIFA over Inter´s alleged Modric approach|
|Mourinho ´has never been so happy´ with unsettled Pogba|
|Manly implode amid Barrett uncertainty, Storm´s Smith injured|
|Sarri certain Hazard is staying at Chelsea|
|Liverpool, Champions League, Manchester derby - The matches De Bruyne will miss due to injury|
|Campbell joins Frosinone from Arsenal on permanent deal|
|Schalke sign Lille´s Mendyl to end left-back hunt|
|Stokes back in England team as Curran drops out|
|Ronaldo doesn´t guarantee Juventus the title, warns Allegri|
|Tuchel keen to guide PSG star Mbappe after World Cup heroics|
|Yuri: I can see Neymar joining Real Madrid|
|Milan pounce for Castillejo as Bacca joins Villarreal permanently|
|De Bruyne to miss three months for Manchester City|
|Manchester City talent Arzani completes Celtic loan|
|I know how precious my career is, says regretful Cipriani|
|Paulo Bento named new South Korea coach|
|Milan complete Laxalt deal|
|Poyet suspended by Bordeaux after outburst against board|
|Tuchel will let Neymar and Cavani settle penalties themselves|
|Hooper: We´re ready, bring on the All Blacks!|
|Outstanding Australia deserve our respect - Read|
|Dragons´ Widdop set for Finals return|