Liverpool and England midfielder Alex Oxlade-Chamberlain will miss the 2018 World Cup after the Premier League club confirmed he has suffered knee ligament damage.
Oxlade-Chamberlain was substituted after 18 minutes of Liverpool's emphatic 5-2 Champions League semi-final first-leg win over Roma at Anfield on Tuesday, following a challenge with visiting wing-back Aleksandar Kolarov.
The 24-year-old, who joined Liverpool from Arsenal in August, has become an integral part of Jurgen Klopp's side over recent months and started both of England's March friendlies against Netherlands and Italy.
However, a statement from Liverpool confirmed his season for club and country is now over.
14 - Since the start of last season, only Dele Alli (17) has more Premier League assists among English players than Alex Oxlade-Chamberlain (14). Absentee. pic.twitter.com/avz1aY5WLp— OptaJoe (@OptaJoe) April 25, 2018
"The extent of the injury means Oxlade-Chamberlain is set to miss the remainder of the campaign for Liverpool, as well as the World Cup finals in Russia with England," the statement read.
"The 24-year-old was assessed by the club’s medical team at Melwood on Wednesday morning and no specific timescale is being placed upon his return to action at this stage.
"However, Oxlade-Chamberlain will now begin a rehabilitation programme to enable him to reach full fitness again as soon as possible, returning to action next season."
After a virtuoso display from Mohamed Salah inspired Liverpool to victory over Roma, Klopp conceded he felt Oxlade-Chamberlain's injury was serious – fears that have now unfortunately been realised.
"Oxlade-Chamberlain's is probably a really bad injury," the German told BT Sport.
"If you can say that before the scan, it's never good news. That's a massive blow for us.
"We have still a few very important games to go and the squad doesn't get any bigger at the moment. We need obviously to be creative in the next few games."
England begin their World Cup campaign against Tunisia on June 18.
Manchester City left-back Benjamin Mendy, who returned to action at the weekend after missing the bulk of this season with cruciate ligament damage, tweeted Oxlade-Chamberlain with a message of consolation and encouragement.
"Bro, sorry to hear that," he wrote. "Wishing you a good recovery. Come back stronger."
Liverpool lie third in the Premier League with three games remaining – three points above Tottenham having played a game more.
|Storm and Raiders snatch dramatic wins|
|Boateng desperate for ´best in the world´ Neuer to play|
|Great players have to play here - Real Madrid´s Marcelo continues Neymar courtship|
|Salah can win Ballon d´Or with Champions League triumph, says Luiz|
|Roland Garros wins ´exactly the same´ for Nadal regardless of Federer involvement|
|Rebels romp past Sunwolves, Crusaders retain top spot|
|Halep ´stronger mentally´ as she seeks first grand slam title|
|Cipriani on bench for Baa Baas clash|
|Ronaldo´s rival Salah shifts focus back to Liverpool versus Real Madrid|
|Two arrested in Kiev after clashes before Champions League final|
|Johnny Nelson leads tributes after death of Brendan Ingle|
|Batshuayi puts off Chelsea plans until after World Cup|
|Devon Smith back in Windies squad, Hamilton earns maiden call-up|
|Thiago hints at uncertain Bayern Munich future|
|Dhananjaya pulls out of Windies tour following death of father|
|I feel great - Kerr keeps faith with Warriors on the brink|
|Ronaldo: I can´t be compared with Salah|
|Buffon agent backs Paris Saint-Germain move|
|ICC confirms smart watches prohibited|
|Real Madrid v Liverpool: Champions League final in Opta numbers|
|Mane sends 300 Liverpool shirts to Senegal village for Champions League final|
|Arthur will not join Barcelona before December, Gremio insist|
|Real Madrid v Liverpool: Key battles in the Champions League final|
|Trout hits 15th HR, Bundy strikes out 14|
|Rockets star Paul dealing with hamstring injury|
|Does he only care about his hair? - Denmark coach Hareide slams Pogba, France|
|Rockets push Warriors to brink of elimination|
|World number 84 Kicker suspended for match-fixing|
|WATCH: Paul shimmies in Curry´s face|
|Copa Libertadores Review: Estudiantes into last 16 after thrilling win over Nacional|
|Ronaldo: Cristiano and Neymar would be good together at Madrid|
|Rockets honour Santa Fe victims, first responders at game five|
|Real Madrid rejected €150m offers for Asensio – agent|
|Marshall, Baldwin react strongly to Trump´s comments on NFL anthem stance|
|Nabura handed six-week ban for wild kick|
|Pedroia to return for Red Sox on Friday|
|Warriors´ Iguodala ruled out for game five against Rockets|
|Na leads as Spieth makes solid start at Colonial|
|James Harden, LeBron James headline 2017-18 All-NBA first team|
|Manchester United target Fred to decide future after World Cup|
|´Incredible´ Salah is like Messi, says Ronaldo|
|Salah a big candidate for Ballon d´Or - Muller|
|Message from coach keeping Masters champion Reed grounded|
|Anybody can really win it - Seles feels French Open is wide open this year|
|Mambo number 5! - Non-league star channels Lou Bega hit|
|Pakistan to stop wearing smart watches after ICC intervention - Hasan|
|Saha hails ´great man´ Ferguson as legendary Man Utd boss continues recovery|
|Emery´s depth of knowledge impressed Arsenal´s Gazidis|
|Conceicao extends Porto contract|
|Lomax impresses as Saints overrun Tigers|
|McIlroy in contention at Wentworth as Bjerregaard sets the early pace|
|Bad light calls time on Thiem, Wawrinka out in Geneva|
|Garitano in, Canales out at Real Sociedad|
|Caparros accepts new role at Sevilla|
|Pliskova downed by Larsson after drawing Serena in Paris|
|They´re using the anthem as fake patriotism - Warriors coach Kerr critical of NFL|
|Lyon win record fifth Women´s Champions League title|
|French Open 2018: Doing the unthinkable - the men most likely to topple Nadal|
|French Open 2018: How can Rafael Nadal be stopped?|
|Steve Smith named as marquee player for Global T20 Canada|
|Can Emre play? Yes he Can... and so can Milner|
|Liverpool working to help fans after flight cancellations|
|Abbas and Hasan torment sorry England|
|Xavi ´thrilled´ to sign two-year Al Sadd extension|
|Holtby extends Hamburg contract despite relegation|
|Nadal begins French Open defence against Dolgopolov|
|Serena drawn to play Pliskova in French Open first round|
|FA condemns assault of match official|
|Bologna confirm Donadoni departure|
|Yates lead halved in Giro d´Italia|