Liverpool and England midfielder Alex Oxlade-Chamberlain will miss the 2018 World Cup after the Premier League club confirmed he has suffered knee ligament damage.
Oxlade-Chamberlain was substituted after 18 minutes of Liverpool's emphatic 5-2 Champions League semi-final first-leg win over Roma at Anfield on Tuesday, following a challenge with visiting wing-back Aleksandar Kolarov.
The 24-year-old, who joined Liverpool from Arsenal in August, has become an integral part of Jurgen Klopp's side over recent months and started both of England's March friendlies against Netherlands and Italy.
However, a statement from Liverpool confirmed his season for club and country is now over.
14 - Since the start of last season, only Dele Alli (17) has more Premier League assists among English players than Alex Oxlade-Chamberlain (14). Absentee. pic.twitter.com/avz1aY5WLp— OptaJoe (@OptaJoe) April 25, 2018
"The extent of the injury means Oxlade-Chamberlain is set to miss the remainder of the campaign for Liverpool, as well as the World Cup finals in Russia with England," the statement read.
"The 24-year-old was assessed by the club’s medical team at Melwood on Wednesday morning and no specific timescale is being placed upon his return to action at this stage.
"However, Oxlade-Chamberlain will now begin a rehabilitation programme to enable him to reach full fitness again as soon as possible, returning to action next season."
After a virtuoso display from Mohamed Salah inspired Liverpool to victory over Roma, Klopp conceded he felt Oxlade-Chamberlain's injury was serious – fears that have now unfortunately been realised.
"Oxlade-Chamberlain's is probably a really bad injury," the German told BT Sport.
"If you can say that before the scan, it's never good news. That's a massive blow for us.
"We have still a few very important games to go and the squad doesn't get any bigger at the moment. We need obviously to be creative in the next few games."
England begin their World Cup campaign against Tunisia on June 18.
Manchester City left-back Benjamin Mendy, who returned to action at the weekend after missing the bulk of this season with cruciate ligament damage, tweeted Oxlade-Chamberlain with a message of consolation and encouragement.
"Bro, sorry to hear that," he wrote. "Wishing you a good recovery. Come back stronger."
Liverpool lie third in the Premier League with three games remaining – three points above Tottenham having played a game more.
|Broad left out of England team for first Test|
|Higuain set to sign for Chelsea but won´t face Tottenham – Sarri|
|McGillvary injury blow for Giants|
|Solari praises Marcelo amid exit rumours|
|A-League Review: Joy and pain for De Jong as Sydney close gap|
|Halfpenny, Davies and Williams set to miss France clash|
|India to rest Kohli from back end of New Zealand tour|
|The hand is good - Farrell expects to be fit to face Ireland|
|Martinez leaves Arsenal for Reading loan|
|Beckham becomes Salford City shareholder|
|Maradona hopes Sala will be found alive|
|Djokovic will not discuss potential Nadal showdown yet|
|A Federer-Nadal double? Even historic scalps may not be enough for Tsitsipas|
|Raonic to assess knee injury, hopes to avoid surgery|
|Barcelona right to fine ´complicated´ Dembele, says Ter Stegen|
|Higuain and Piatek on the move on busy day for Milan|
|Philippe and Vince humble the Hurricanes|
|Nishikori: I couldn´t beat anybody on one leg|
|Boateng poised for debut as Barcelona axe Suarez|
|Shami sets record in crushing win after sun stops play|
|Sala search focused on possible use of life raft|
|Pouille exceeds own expectations with run to Aus Open semis|
|Nishikori retirement sees Djokovic through to semi-finals|
|A golden boy, a guy you want to love - Delecroix pays emotional tribute to Sala|
|Richardson, Patterson to make Australia debuts against Sri Lanka|
|Police resume search for missing Sala plane|
|Pouille upsets Raonic to reach Australian Open semis|
|Dunk sees Stars past Strikers|
|How Serena gave up 5-1 lead – the key moments of loss to Pliskova|
|Pliskova enjoys ´best comeback´ after stunning Serena|
|Serena not blaming ankle injury for Australian Open loss|
|Mavericks capitalise on Clippers´ turnovers, pick up win in Smith´s return|
|Pliskova saves four match points to stun Serena with comeback win|
|Anthony ´can only make´ a team better, says Iverson|
|Henry more worried about Monaco´s future than his own|
|Osaka powers past Svitolina in Melbourne|
|Harden on Anthony trade: It kind of sucks that it didn´t work out|
|Redskins remain ´optimistic´ QB Alex Smith will play again|
|Patriots coach Belichick says Rams´ Donald is ´pretty much unblockable´|
|PSG fined €100,000 by LFP over player-recruitment practices|
|I´m not his father - Guardiola demands Mendy matures|
|Sykes record in vain as Banvit claim victory|
|Usain Bolt calls time on football career|
|Otamendi not happy at Man City, says Guardiola|
|Workaholic Woods learning to rest as he prepares for 2019 debut|
|Henry´s Monaco dumped out of Coupe de France|
|Qatar can win Asian Cup, says Sanchez|
|Tim Howard to retire following 2019 MLS season|
|Koscielny backs Bellerin to return from injury ´stronger than before´|
|Chiefs fire DC Bob Sutton after AFC Championship loss to Patriots|
|Reyes returns to Spain with second-tier strugglers Extremadura|
|Emiliano Sala: Profile of Cardiff City striker missing after joining from Nantes|
|Messi rested for Sevilla trip, Boateng set for debut|
|Nuno fined over pitch celebration in Leicester win|
|Nadal unfazed by another Next Gen opponent in Tsitsipas|
|Ulster hand lifetime ban to spectator after Zebo abuse|
|Phehlukwayo´s career-best day inspires Proteas against Pakistan|
|Bournemouth pounce for Brentford´s Mepham|
|You say all signings are controversial – Valverde defends Boateng arrival|
|Search for missing Sala plane suspended|
|Kohli and Williamson display mutual respect as India and Black Caps prepare for battle|
|Qatar 1 Iraq 0: Al Rawi free-kick books quarter-final spot|
|Ba joins Adebayor and Robinho at Istanbul Basaksehir|
|BREAKING NEWS: Tottenham´s Alli out until March with hamstring injury|
|Fit-again Joseph added to England squad|
|It is very, very serious for us - Tuchel wants midfielder in January window|
|Lakers expect Rajon Rondo back Thursday as LeBron James continues rehab|
|Atletico Madrid boosted as Koke thigh injury revealed to be minor|
|South Korea 2 Bahrain 1 (after extra time): Kim Jin-su seals quarter-final spot|
|AC Milan confirm Zapata thigh injury|